白物质的差异 家庭中的结构网络 重度抑郁症和自杀倾向的风险:一个连接组分析
medRxiv : the preprint server for health sciences
|September 21, 2023
概括
患有抑郁症或自杀倾向的家庭病史的人,大脑连接性降低,特别是在皮层和皮层以下区域之间. 这种大脑范围内的信息处理受损,即使没有个人精神病理,也可能发生.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
背景情况:
- 抑郁症和自杀是全球导致残疾和死亡的主要原因,家庭因素很强.
- 以前的研究表明,在有抑郁病史的个体中,神经生物学的差异,如白质连接性下降,但专注于孤立的区域.
- 这项研究调查了三代家庭研究中基于家庭抑郁或自杀史的脑网络结构差异.
研究的目的:
- 用图形理论模型研究大脑网络差异.
- 为了检查家庭有抑郁症或自杀倾向的病史是否会影响大脑网络结构.
- 分析三代纵向家庭研究中的这些差异.
主要方法:
- 利用三代临床医生采访来分类家庭患抑郁和自杀的风险.
- 从96个个体的扩散张力成像数据构建加权网络模型,重点关注108个皮层和皮层下区域.
- 采用图形理论测量 (集群系数,路径长度,效率) 和基于网络的统计数据进行群组比较,调整个人精神病理.
主要成果:
- 患有抑郁症的家庭风险较高的个体表现出较低的聚类系数,表明邻近地区之间的连接性减少.
- 基于网络的统计数据显示,即使在控制个人精神病理后,抑郁症和自杀倾向的家庭风险较高的个体中,存在虚连接的子网络.
- 这些受影响的子网络涉及到关键的皮质-子皮质连接,包括诸如上额叶皮质,乳头,前皮质和皮质等区域.
结论:
- 抑郁症和自杀倾向的家族病史与皮质下和皮质大脑区域之间的低连接性有关.
- 研究结果表明,与家族风险相关的全脑信息处理受损的可能性很大.
- 这些神经生物学变化甚至可能存在于没有个人精神病诊断的个体中.
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