关键癌症患者急性呼吸系统衰竭的专家共识 (2023)
Hai-Jun Wang1, Wei Chen2, Hong-Zhi Wang3
1Department of Intensive Care Unit, National Cancer Center / National Clinical Research Center for Cancer / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
这一共识提供了基于证据的建议,用于诊断和治疗急性呼吸衰竭 (ARF) 严重癌症患者,指导临床实践以改善结果.
科学领域:
- 关键护理医学 关键护理医学
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
背景情况:
- 急性呼吸衰竭 (ARF) 在危急癌症患者中提出了重大挑战.
- 现有的指导方针可能无法充分解决这种人群中ARF的独特复杂性.
- 基于证据的建议对于优化诊断和治疗策略至关重要.
研究的目的:
- 建立基于共识的,基于证据的建议,以诊断和治疗急性癌症患者的ARF.
- 通过结构化的 PICO 框架和 GRADE 方法来解决常见的临床问题.
- 为了改善临床决策和患者的结果,在这个特定的队列.
主要方法:
- 使用PICO (人口,干预,比较,结果) 原则开发六个临床问题.
- 进行全面的文献搜索和元分析,以收集相关证据.
- 应用GRADE (推评估,开发和评价的分级) 方法来获得专家小组的共识.
主要成果:
- 强有力的建议有利于转基因下一代测序 (mNGS) 以快速诊断肺部感染.
- 身体外膜氧化 (ECMO) 不是常规的,但可能有利于选定的ARDS患者.
- 免疫检查点抑制剂增加了肺炎的风险;早期气管切除可能有利于长时间的通风.
- 建议使用高流量鼻氧和非侵入性通风作为ARF的第一线策略.
- 对敏感患者的瘤压缩相关的ARF紧急化疗的弱建议.
结论:
- 开发的建议为关键癌症患者的ARF管理提供了一个框架.
- 基于证据的指导可以提高诊断准确性和治疗干预措施.
- 实施这些建议有可能改善患者的治疗结果.
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