在LAAOS III中使用口服抗凝剂和左耳塞
Stuart J Connolly1, Jeff S Healey1, Emilie P Belley-Cote1
1Population Health Research Institute, Hamilton Health Sciences, McMaster University, Ontario, Canada (S.J.C., J.S.H., E.P.B.-C., K. Balasubramanian, K. Brady, P.J.D., M.S., C.R., S.Y., R.P.W.).
Circulation
|September 21, 2023
概括
在接受心脏手术的心房动患者中,左心房塞有效降低了中风风险. 无论患者是否使用口服抗凝剂 (OAC) 治疗,这种益处都是一致的.
科学领域:
- 心脏病学
- 血管外科
- 血栓形成研究
背景情况:
- 在心脏手术期间,左心房尾 (LAA) 已被证明可以降低心脏动患者的中风风险.
- 口服抗凝剂 (OAC) 治疗的变化可能会影响LAA封闭的有效性.
研究的目的:
- 检查LAA封闭对中风风险降低与OAC治疗相关的影响.
- 要确定LAA封闭的好处是否独立于OAC的使用.
主要方法:
- 利用LAAOS III试验的数据,在后续访问中收集OAC使用信息.
- 用时间依赖的共变量来分析中风风险.
- 在随机化后多个时间点评估中风风险.
主要成果:
- 在不同使用OAC的患者群体中,LAA封闭显示出一致的中风风险降低 (HRs从0. 63到0. 76).
- 使用OAC作为时间依赖的共变量进行的分析表明,无论OAC状态如何,LAA阻塞都会出现类似的中风减少.
结论:
- 无论同时接受OAC治疗,LAA封闭的降低血栓风险效果是一致的.
- 对于心房的患者来说,LAA封闭是独立于OAC使用的有价值的中风预防策略.
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