一种来自海洋鱼类衍生真菌Alternaria sp. 的新型 antraquinone 衍生物. X11212 是一个字母
Xiaoyuan Xu1, Gang Li1, Rao Fu1
1Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, Shandong, People's Republic of China.
Natural product research
|September 21, 2023
概括
一种来自海洋鱼类的新型真菌产生了一种新型的 antraquinone, altermodinacid A 和已知的衍生品. 这种化合物被评估为其细胞毒性,抗菌性和质量检测抑制作用.
科学领域:
- 自然产品化学 自然产品化学
- 海洋微生物学 海洋微生物学
- 菌类学 菌类学是指菌类学.
背景情况:
- 海洋衍生真菌是生物活性天然产品的丰富来源.
- 适应盐水环境的耐菌可能会产生独特的代谢物.
- 菌的二次代谢物在医学和农业中具有多样化的应用.
研究的目的:
- 从一种海洋衍生的耐药真菌中分离和描述新型化合物.
- 为了评估新发现的化合物阿尔特莫迪纳西德A的生物活性.
- 探索海洋真菌作为生物活性分子来源的潜力.
主要方法:
- 使用色谱技术分离和净化真菌代谢物.
- 使用质谱法 (MS) 和核磁共振 (NMR) 谱法阐明化合物的结构.
- 生物活性查包括细胞毒性,抗菌检测,抗农业病原体活性和定数感应抑制.
主要成果:
- 一种新的 antraquinone,altermodinacid A (1),被分离和结构性地鉴定出来.
- 从真菌提取物中也确定了五种已知的 antraquinone 衍生物 (2-6).
- 阿尔特莫迪纳西德A表现出细胞毒性作用,抗农业病原体活性,抗菌活性,以及定数感应抑制潜力.
结论:
- 海洋衍生的耐药真菌 *Alternaria* sp. X112是结构多样化的 antraquinones 的来源.
- 由于其多方面的生物活性,Altermodinacid A代表了进一步研究的有希望的化合物.
- 这项研究强调了海洋微生物在发现新生物活性天然产品方面的潜力.
相关概念视频
01:23Red Algae
Red algae, also known as rhodophytes, are primarily found in marine environments, though some species inhabit freshwater and terrestrial ecosystems. These organisms exist in both unicellular and multicellular forms, with some multicellular varieties reaching macroscopic sizes.As phototrophic organisms, red algae contain chlorophyll a; however, their chloroplasts lack chlorophyll b. Instead, they possess phycobiliproteins, which serve as major light-harvesting pigments, similar to those found in...
01:19Other Algae
The group Stramenopiles include some phototrophic microorganisms. Members of this group possess flagella covered in numerous short, hairlike extensions, a feature that inspired the group's name, derived from the Latin words for "straw" and "hair." Some of the main categories of Stramenopiles include diatoms, golden algae, and brown algae.Diatoms are unicellular, photosynthetic eukaryotes, with over 200 known genera. They play a key role in the planktonic communities of both marine and...
01:15Antifungal Agents
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...