气管癌的生存结果和预测因素
Nidhi Desai1, Benjamin R Zambetti1, Denise L Wong1
1Division of Thoracic Surgery and Department of Surgery, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee, USA.
手术切除为原发性气管癌患者提供了最佳的生存率. 放射治疗对具有正边缘 (R1/2) 的患者有好处,而化学疗法无论切除边缘如何,都没有对生存的影响.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 辐射瘤学 辐射瘤学
背景情况:
- 初级气管癌很少见,并与患者的生存率差有关.
- 手术切除是主要的治疗方法,但化疗和放射治疗的作用还不清楚.
研究的目的:
- 研究不同治疗方式对原发性气管癌患者的生存结果的影响.
- 为了确定影响这种患者群体生存的因素.
主要方法:
- 来自国家癌症数据库 (2004-2015) 的1726名初级气管癌患者的回顾性分析.
- 收集的数据包括患者和瘤特征,治疗方式和生存率.
- 考克斯回归分析用于评估与生存相关的因素.
主要成果:
- 手术切除显著改善了生存率 (中位数为89个月,总体为28.5个月).
- 腺状囊性癌 (ACC),辐射和手术切除与改善的生存率有关,而年龄的增加减少了生存率.
- 对于R1/2切除,辐射改善了生存率,但化疗没有影响结果. 对于R0切除,化疗和放射治疗都没有影响生存率.
结论:
- 手术切除是对原发性气管癌最有效的治疗方法,显著改善了生存率.
- 放射治疗对具有积极外科边缘 (R1/2) 的患者提供了生存益处,但对于具有明显边缘 (R0) 的患者则没有.
- 化疗似乎不会影响原发性气管癌的生存结果,无论边际状况如何.
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