智慧地使用抗生素
Jae Jung1, Francesca Cozzi, Graeme N Forrest
1Rush University Medical Center, Chicago, Illinois, USA.
Current opinion in infectious diseases
|September 21, 2023
概括
较短的抗生素疗程和早期切换到口服治疗对于各种感染是有效的. 人工智能显示出优化在传染病中抗生素使用的前景.
科学领域:
- 传染性疾病 传染性疾病
- 抗微生物药物管理委员会
- 人工智能在医学中的应用
背景情况:
- 优化抗生素治疗对于打击抗菌素耐药性和改善患者治疗结果至关重要.
- 目前的做法往往涉及长期使用抗生素和静脉注射,这可能并不总是必要的.
研究的目的:
- 审查较短的抗生素疗程在传染病中的作用.
- 评估早期静脉输入到口服治疗的疗效和安全性.
- 探索人工智能在抗菌药物管理中的新兴作用.
主要方法:
- 对抗生素治疗持续时间研究的文献综述.
- 在各种感染中,对静脉注射到口服转换的证据分析.
- 评估人工智能在抗生素管理中的当前和未来应用.
主要成果:
- 较短的抗生素疗程 (例如3-7天) 对细菌病和肺炎等特定感染的标准持续时间不逊色.
- 从静脉注射到口服抗生素的早期切换是安全,有效和经济高效的治疗感染,如细菌病,内心炎,骨/关节感染.
- 建议在干净的外科手术过程中使用单剂量塞法佐林,强调准确的抗生素选择和过敏评估.
结论:
- 实施更短的抗生素持续时间和促进早期的静脉注射到口服的转换代表了抗菌药物管理的可实现策略.
- 人工智能具有自动化和增强抗生素使用优化的潜力,尽管需要进一步验证.
相关概念视频
Antibiotic Selection
54.6K
Overview
54.6K
Development of Antibiotic Resistance
33
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
33
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
14
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
14
Methods for Controlling Microbial Growth
59
Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
59
Biological Methods for Microbial Control
55
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
55
Urine Studies II: Urine Culture and Sensitivity Test
38
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
38


