通过共识命名法,估计脂肪性肝病的全国流行率和分类,使用共识命名法
Brian P Lee1,2, Jennifer L Dodge1,3, Norah A Terrault1,2
1Division of Gastroenterology and Liver Diseases, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Hepatology (Baltimore, Md.)
|September 21, 2023
概括
新的脂肪性肝病 (SLD) 命名重新分类脂肪性肝病,显示患病率为34.2%. 与代谢功能障碍相关的SLD (MASLD) 是最常见的形式,影响疾病理解和患者识别.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 现在被称为脂肪性肝病 (SLD),根据新的多社会共识命名法.
- 这种新的SLD分类对疾病流行率和患者表型的影响需要研究.
研究的目的:
- 使用新命名法估计SLD及其分类的全国流行率.
- 分析跨人口和临床亚组的SLD患病率,包括晚期肝纤维化.
- 在新的SLD框架内探索代谢风险因素,酒精消费和晚期纤维化之间的关系.
主要方法:
- 利用了国家健康和营养检查调查 (2017-2020) 的数据.
- 包括成年参与者与完整的振动控制的短暂弹性体测量措施.
- 定义的SLD和子分类 (MASLD,MetALD,ALD等) 根据共识命名法.
主要成果:
- 在7367名参与者中,估计SLD总流行率为34.2%.
- 与代谢功能障碍相关的SLD (MASLD) 占病例的31.3%.
- 探索性分析表明,代谢因素,酒精摄入量和晚期肝纤维化之间存在关联.
结论:
- 新的SLD命名体系提供了比以前的NAFLD术语更好的分类.
- 需要进一步的研究来完善SLD的分类及其临床影响.
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