混合胺盐延长释放 (MAS-ER) 作为可卡因使用障碍的行为治疗增强策略:一项随机临床试验
Kenneth M Carpenter1, C Jean Choi2, Cale Basaraba2
1Division on Substance Use Disorders, New York State Psychiatric Institute.
Experimental and clinical psychopharmacology
|September 21, 2023
概括
在行为治疗中添加混合胺盐延长释放 (MAS-ER) 并没有改善可卡因使用障碍 (CUD) 的戒断率. 虽然MAS-ER降低了渴望强度,但它并没有显著提高CUD的整体治疗结果.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 心理社会干预是可卡因使用障碍 (CUD) 的标准,但有效性各不相同.
- 基于安非他胺的治疗方法对那些不仅对行为治疗有反应的CUD患者有潜力.
研究的目的:
- 评估是否用混合安非他胺盐延长释放 (MAS-ER) 增强行为疗法可以改善患有CUD的成年人的戒断率.
- 评估MAS-ER对可卡因渴望和治疗持久性的影响.
主要方法:
- 145名患有CUD的成年人接受了为期1个月的技能干预和应急管理.
- 没有达到3周戒断的参与者被随机分配给MAS-ER (80 mg/天) 或安慰剂10周.
- 禁欲是通过尿液毒理学和自我报告来衡量的;渴望和保留也被评估.
主要成果:
- 在MAS-ER (15.6%) 和安慰剂 (12.2%) 组之间的3周禁酒率没有显著差异.
- MAS-ER组报告说,想要可卡因的程度降低了,但对感知到的改善或想要的频率没有差异.
- 与行为反应者相比,在两组药物治疗中,保留率都更高.
结论:
- 用MAS-ER增加行为治疗并没有显著增加CUD的戒断率.
- MAS-ER可能有助于降低可卡因渴望的强度,并改善治疗的持续性.
- 需要进一步的研究来确定CUD治疗中对药物治疗的反应的预测因素.
更多相关视频
10:02Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
Published on: March 12, 2020
15.7K
07:51A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
10.6K
相关概念视频
01:30Attention-Deficit/Hyperactivity Disorder
85
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
85
01:24CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
224
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
224
01:28Adrenergic Agonists: Mixed-Action Agents
771
Mixed-action adrenergic agonists, like ephedrine and pseudoephedrine, directly and indirectly affect adrenergic receptors. These agents stimulate adrenoceptors and indirectly release stored neurotransmitters, amplifying the adrenergic response.
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
771
01:25Adrenergic Agonists: Indirect-Acting Agents
1.7K
Indirect-acting adrenergic agonists potentiate the effects of endogenous catecholamines through different mechanisms without directly binding to adrenoceptors.
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral...
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral...
1.7K
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
147
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
147
01:29Stimulants
237
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
237