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5 -阿尔法-二基孕可能有助于感知处理和注意复发性复发性多发性硬化症病例的注意力

Emin Ozcan¹, Rana Cagla Akduman¹, Sevim Eyupoglu²

¹Department of Neurology, Yeditepe University Hospital, Istanbul, Turkey.

Neurological research

|September 21, 2023

概括

在患有复发性缓解性多发性硬化症 (MS) 的患者中,神经类固醇水平,特别是5-α-二基 (5-α-DHP),可能较低. 较低的5-α-DHP可能与认知缺陷相关,这表明在MS相关的认知变化中发挥了作用.

科学领域:

神经内分泌学神经内分泌学
神经免疫学神经免疫学
认知神经科学认知神经科学

背景情况:

神经类固醇 (NSs) 在中枢神经系统中合成,并影响髓化,质分化和认知功能.
对NS水平的改变与各种神经疾病有关.
了解多发性硬化症 (MS) 中的NS动态对于解决认知障碍至关重要.

研究的目的:

研究神经类固醇水平之间的关系,特别是5-α-二二前 (5-α-DHP) 和原 (ALPG),以及复发性缓解性MS患者的认知功能.
探索5-α-DHP和ALPG水平与认知测试表现之间的相关性.
评估疾病严重程度 (EDSS) 和持续时间与认知变化之间的关联.

主要方法:

一个由43名经过良好控制的复发性缓解性多发性硬化症患者和21名健康对照 (HC) 组成的研究小组.
使用神经心理测试简短重复电池 (BRBNT) 评估认知功能,包括符号数字模式测试 (SDMT) 和空间回忆测试 (SPART).
在所有参与者中测量了5-α-DHP和ALPG的血清水平.

主要成果:

与HC相比,MS组的5-α-DHP水平中位数明显较低 (p=0.02).
在MS患者和HC患者中,5-α-DHP水平与SDMT得分正相关 (p<0.05).
在MS患者中,更高的扩展残疾状态量表 (EDSS) 分数和更长的疾病持续时间与SPART和SDMT的分数较低有关.

结论:

即使在经过良好控制的复发性缓解性多发性硬化症中,也可能会降低5-α-二二前 (5-α-DHP) 水平.
5α-DHP可能在MS患者的认知处理,注意力和感知能力中发挥作用.
需要进一步的研究来探索针对神经类固醇的治疗策略,以提高MS的认知能力.

关键词:

5α-二基孕激素的使用方法多发性硬化症是多发性硬化症.这是神经类固醇.在所有孕产妇中,所有孕产妇中,所有孕产妇中,所有孕产妇中,所有孕产妇中,所有孕产妇中,所有孕产妇中,所有孕产妇中.认知功能认知功能

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