在糖尿病相关的认知功能障碍中,肠道微生物群对炎症性细胞因子和微RNA的调节
Hongying Huang1, Tong Zhao1, Jinchen Li1
1School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, People's Republic of China.
Applied microbiology and biotechnology
|September 21, 2023
概括
与认知功能障碍相关的2型糖尿病与单独的糖尿病相比,显示出明显的肠道细菌. 特定的肠道微生物,炎症性细胞因子如IL-12,和microRNAs如miR-142-5p可能会将肠道健康与糖尿病中的大脑功能联系起来.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 2型糖尿病 (T2DM) 经常与认知障碍同时发生,称为糖尿病相关认知功能障碍 (DACD).
- 肠道微生物群的改变与糖尿病患者观察到的认知缺陷有关.
- 诸如食脂肪酸,炎症性细胞因子和microRNAs (miRs) 等因素影响认知表现,但它们在T2DM相关的认知功能障碍中的作用需要进一步阐明.
研究的目的:
- 调查T2DM患者与没有认知障碍 (DACD) 之间的肠道微生物组合的差异.
- 探索红细胞膜脂肪酸,炎症性细胞因子 (例如IL-12) 和微RNA (例如miR-142-5p) 与DACD中的肠道微生物群的关联.
- 阐明肠道微生物群影响T2DM认知功能的潜在机制.
主要方法:
- 在DACD和T2DM患者组之间对肠道微生物群组成 (属级) 的比较分析.
- 测量血炎性细胞因子 (IL-12) 和微RNA (miR-142-5p) 的水平.
- 在特定的肠道微生物属,炎症标志物和microRNAs之间进行相关性分析.
主要成果:
- 特定的细菌系,包括norank_f_Eubacterium_coprostanoligenes_group,Acidaminococcus,Enterorhabdus和norank_f_Clostridium_methylpentosum_group,在DACD患者中更为丰富.
- 在DACD患者中,血IL-12度显著高于DACD患者,并且与norank_f_Eubacterium_coprostanoligenes_group.正相关.
- 血中的miR-142-5p水平与Enterorhabdus和norank_f_Eubacterium_coprostanoligenes_group显著正相关.
结论:
- 肠道微生物群的组成在有或没有认知障碍的T2DM患者之间有所不同.
- 肠道微生物组可能通过涉及IL-12和miR-142-5p的途径影响T2DM中的认知功能.
- 研究结果表明,通过调节肠道微生物群,在糖尿病患者中管理认知功能障碍的新型治疗点.
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