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Updated: Jul 16, 2025

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

在治疗动脉静脉形形时,针对微环境

Caroline T Seebauer¹, Benedikt Wiens², Constantin A Hintschich²

¹Department of Otorhinolaryngology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany. caroline.seebauer@ukr.de.

|September 21, 2023

概括

机械压力增加了动脉静脉形形 (AVMs) 中的VEGF. 作为VEGF抑制剂的贝瓦齐祖马布 (bevacizumab) 降低了AVM细胞生长和网络形成,显示为AVM治疗的前景.

科学领域:

血管生物学血管生物学
在瘤学瘤学.
药理学药理学是指药理学的学科.

背景情况:

外动脉静脉形 (AVM) 是一种罕见的血管异常.
由于高血管压力和内皮细胞的机械压力,AVM会引起疼痛,出血和不受控制的生长.
除了手术和干预性放射学外,还需要新的药理疗法.

研究的目的:

研究机械应激对AVM内皮细胞的作用.
评估VEGF抑制剂的thalidomide和bevacizumab在控制AVM细胞增殖和网络形成方面的疗效.
评估贝瓦齐祖马布在无法切除的AVMs患者的临床有效性和安全性.

主要方法:

三名患者的AVM细胞经历了循环的机械拉伸.
thalidomide和bevacizumab对它们对细胞增殖和循环网络形成的影响进行了测试.
测量了VEGF基因和蛋白质的表达.
贝瓦西祖马布被给予了三名无法切除的AVM患者.

主要成果:

机械应激增加了AVM内皮细胞中的VEGF基因和蛋白质表达.
thalidomide和bevacizumab都降低了内皮AVM细胞的增殖.
贝瓦齐祖马布在机械应力下抑制了循环网络的形成,并降低了VEGF的表达.
在八个月以上的患者中,使用贝瓦齐祖马布的临床治疗控制了出血,脉动和疼痛,没有报告的副作用.

结论:

机械应力加剧了AVM中的VEGF表达.
贝瓦西祖马布在体外有效地抑制AVM内皮细胞的增殖和网络形成.
贝瓦西祖马布在治疗无法切除的AVM症状方面表现出临床疗效,具有良好的安全性.

关键词:

动脉静脉发育不良的发生贝瓦西祖马布 (bevacizumab) 是一种药物.快速流动形快速流动形机械应力机械应力机械应力微观环境是一个微观环境.泰利多胺是一种在VEGF中,VEGF是VEGF.这是一种VEGF抑制剂.

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