在患有早期乳腺癌的非常年轻女性中抑制卵巢功能的低最佳使用:真实世界的数据研究研究
Ana Heredia1,2, Benjamín Walbaum1,3,4, María Vidal5
1Departamento de Hematología-Oncología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago, Chile.
Breast cancer research and treatment
|September 21, 2023
概括
卵巢功能抑制 (OFS) 在早期激素受体阳性乳腺癌 (BC) 的年轻女性中未得到充分利用. 雷根综合风险 (RCR) 评分有效地识别了可能从OFS中受益的高风险患者,并与生存结果有关.
科学领域:
- 在瘤学瘤学.
- 生殖内分泌学 生殖内分泌学
背景情况:
- 年轻女性乳腺癌 (BCYW) 面临着独特的挑战,因为其攻击性增加和预后较差.
- 卵巢功能抑制 (OFS) 在激素受体阳性 (HR +) BCYW中显示出改善的生存率.
- 里根综合风险 (RCR) 评分是一个预测工具,用于识别HR + BC候选人OFS.
研究的目的:
- 描述早期HR+/HER2-BCYW.的智利队列.
- 评估OFS的使用情况及其对这一群体的预后影响.
- 评估在智利BCYW患者中RCR得分的有用性.
主要方法:
- 对年龄≤35岁的HR+/HER2-BC患者进行了回顾性人口队列研究 (2001-2021).
- 对临床病理特征,治疗策略 (内分泌疗法,化疗,OFS) 和生存率的分析.
- 评估RCR得分与患者存活率之间的关联.
主要成果:
- 包括143名BCYW患者 (2.9%的早期BC注册);中位数年龄为31.
- 93%接受了内分泌疗法 (ET);18%接受了OFS (主要是手术性卵巢切除术).
- 较高的RCR得分与较差的整体存活率相关;在接受化疗加ET的患者中,RCR更高.
结论:
- 在这个智利队列中,在早期HR+/HER2-BCYW中,OFS利用率仍然很低 (<20%).
- RCR得分是一个有价值的预后工具,与生存结果相关,无论治疗方式如何.
- RCR可以帮助识别可能受益于OFS的高风险BCYW患者.
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