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验证工具,以检测和停用人乳中猿病毒的有效性.

Alex E Clark1, Annalee Furst2, Kristija Sejane2

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病毒 (MPXV) 可以在人乳中检测到,但仍然具有传染性. 持有人巴氏杀菌有效地使HM中的MPXV无活化,降低了接收捐赠奶的婴儿的传播风险.

关键词:
母乳养 哺乳期 母乳养持有者的巴氏消毒方式人类母乳是人类的母乳.的水病毒病毒.一个MPOX的MPOX.莫波克斯诊断系统的诊断

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科学领域:

  • 病毒学 病毒学
  • 公共卫生 公共卫生
  • 哺乳期科学 哺乳期科学

背景情况:

  • 人母乳 (HM) 对婴儿健康至关重要,需要安全监测.
  • 麻疹病毒 (MPXV) 对母乳养双胞胎构成潜在的风险.
  • 了解MPXV在HM中的稳定性和无活化对于婴儿保护至关重要.

研究的目的:

  • 评估在HM中检测MPXV的方法.
  • 为了确定标准的Holder消毒是否会在HM中使MPXV失活.
  • 评估MPXV通过HM传输的风险.

主要方法:

  • MPXV被添加到HM和病毒传输媒体 (VTM).
  • 用研究和临床定量聚合酶连锁反应 (qPCR) 试验分析了样本.
  • 在HM中感染的MPXV经过冷解,室温化和Holder消毒,然后进行斑块检测.

主要成果:

  • qPCR检测到HM中的MPXV,尽管与VTM相比敏感性降低.
  • 在冷解或室温储存后,MPXV在HM中仍然具有传染性.
  • 持有人巴氏杀菌显著降低了传染性MPXV标位 (>2000倍),低于检测极限.

结论:

  • 临床qPCR测试可以在HM中检测MPXV,但检测极限高于VTM.
  • MPXV可以在HM中保持生存,从而构成潜在的传播风险.
  • 持有人巴氏杀菌是一种有效的方法,可以在HM中使MPXV失活,从而降低向婴儿传播的风险.