最近关于糖尿病视网膜病变和其管理的病原发生的最新见解
Arpon Biswas1,2, Abhijit Deb Choudhury1,2, Sristi Agrawal1,3
1Pharmaceutics and Pharmacokinetic Division, CSIR-Central Drug Research Institute, Lucknow, India.
概括
糖尿病视网膜病变 (DR) 涉及复杂的分子通路和氧化应激,导致视力丧失. 本综述探讨了临床试验中的DR病原,治疗方法和新疗法.
科学领域:
- 眼科和分子生物学
背景情况:
- 糖尿病视网膜病变 (DR) 是糖尿病的严重并发症,由于视网膜血管损伤导致失明.
- 由于复杂的生化途径和眼组织的复杂性,管理DR是具有挑战性的.
研究的目的:
- 综合审查DR病变的分子途径,包括多,六胺,PKC,JAK/STAT和RAS.
- 探索DR的当前和新兴药物治疗方法,包括传统药物,重用药物和新型管道治疗方法.
主要方法:
- 在PubMed,Scopus,谷歌学者和科学网络的系统文献搜索.
- 关键词包括"糖尿病视网膜病变"",分子通路"",药理疗法"和"临床试验".
主要成果:
- 确定了关键的分子通路 (多醇,六胺,PKC,JAK/STAT,RAS),有助于DR病原和氧化应激.
- 审查了常规疗法 (皮质类固醇,抗VEGF,NSAID),并突出了临床试验中重新定位的药物,植物药物和新药的潜力.
结论:
- 抗氧化激素的发病是复杂的,涉及多个分子通路和氧化应激.
- 一系列的治疗策略,从既定到新的,正在研究DR治疗.
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