在podocytopathies中血的重要性
Dorota Marchel1, Howard Trachtman1, Maria Larkina2
1Department of Pediatrics, Division of Nephrology, University of Michigan, Ann Arbor, Michigan.
Clinical journal of the American Society of Nephrology : CJASN
|September 21, 2023
概括
血 (尿液中的血液) 是 podocytopathies 常见的,并预测更糟糕的结局. 早期检测出血流可以帮助管理这些蛋白尿性脏疾病.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内部医学 内部医学
背景情况:
- 血是podocytopathies中常见的发现,这是蛋白质性脏疾病的一组.
- 在这些条件下,出血症的预后意义尚未得到充分确立.
- 这项研究调查了 podocytopathies 中血的流行率和预测价值.
研究的目的:
- 为了确定患有膜性脏病,最小变化疾病和FSGS的患者中出血的患病率.
- 评估血和脏相关结果在这些podocytopathies之间的关联.
- 评价血作为功能下降和蛋白尿症缓解的独立预测因素.
主要方法:
- 分析了瘤综合征研究网络和治愈淋巴细胞瘤症队列的数据.
- 包括患有膜性病,最小变化疾病和超过24个月的FSGS的参与者.
- 多变量Cox比例危险模型用于评估复合结果 (功能衰竭或EGFR下降) 和蛋白尿症缓解 (UPCR<0.3 mg/mg).
主要成果:
- 在1516名参与者中,33%的人患有出血症.
- 血与年龄较大,膜性脏病,活检后时间较短,尿蛋白与肌素比率 (UPCR) 更高有关.
- 经过调整后的分析显示,出血症独立预测了较高的脏不良结果风险 (HR, 1.31) 和较低的蛋白尿缓解率 (HR, 0.80).
结论:
- 血在患有膜性腎病,最小變化疾病和FSGS的患者中普遍存在.
- 血是这些 podocytopathies 中更糟糕的脏相关结果的显著独立预测因素.
- 出血症的存在表明功能丧失的风险较高,蛋白尿症缓解的可能性降低.
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