奇怪的骨骨性骨性染色体扩散 (诺拉损伤):一个叙述性审查
Ipponi Edoardo1, Ferrari Elisa1, Ruinato Alfio Damiano1
1University of Pisa: Department of Orthopedics and Trauma Surgery.
Acta medica Lituanica
|September 21, 2023
概括
奇怪的侧骨骨质多样性扩散 (BPOP),也称为诺拉病变,是一种罕见的骨疾病. 手术切除是主要的治疗方法,但复发是常见的,需要仔细的诊断和治疗.
科学领域:
- 整形外科手术 整形外科手术
- 病理学 病理学 病理学
- 放射学 放射学是一门学科.
背景情况:
- 奇怪的侧骨骨质突变扩散 (BPOP) 或诺拉病变是一种罕见的骨疾病,其病因不明确,通常被认为是一种类似瘤的病变或良性瘤.
- 现有的文献仅限于病例报告和小型病例系列,因为它的发病率很低.
- 本综述综合了有关BPOP自然史,形态学和预后的当前文献.
研究的目的:
- 基于现有文献,提供BPOP的全面概述.
- 总结诺拉病变的自然史,诊断特征和预后因素.
- 更新对这种罕见的骨疾病的了解.
主要方法:
- 在1983年至2021年期间对BPOP的研究进行了系统的文献搜索.
- 收集的数据包括病因,发病,患者人口统计,病变特征,临床表现,成像,病理学,治疗和预后.
- 分析的重点是总结识别的研究的发现.
主要成果:
- 确定了322例BPOP病例,诊断时的平均年龄为34.3岁,没有性别偏好.
- 手和脚是受影响最常见的部位;在14.7%的病例中报告了创伤,38.7%的病例经历了疼痛.
- 典型的放射和显微镜图案存在,但组织学确认是强制性的. 手术切除是主要的治疗方法,复发率为37.4%.
结论:
- BPOP是一种罕见的良性实体,在骨病变的差异诊断中至关重要,特别是在骨区域.
- 准确的诊断需要仔细评估,包括成像和强制性组织学分析.
- 建议使用广泛的外科切除边缘,以减少局部复发的显著风险.
相关概念视频
01:29Bone Disorders
3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
01:31Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
01:27Growth of Cartilage and Bone Tissue
3.4K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.4K
01:24Bone Formation by Endochondral Ossification
4.6K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
4.6K
01:29Blood and Nerve Supply to the Bones
11.1K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
11.1K