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相关概念视频

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.8K
Cross-reactivity00:42

Cross-reactivity

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Overview
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

528
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
528
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

620
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
620
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

858
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
858

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相关实验视频

Updated: Jul 16, 2025

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
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Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

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识别B细胞表位的多重视角和挑战

Nishant Kumar1, Nisha Bajiya1, Sumeet Patiyal1

  • 1Department of Computational Biology, Indraprastha Institute of Information Technology, New Delhi, India.

Protein science : a publication of the Protein Society
|September 21, 2023
PubMed
概括

本综述全面涵盖了B细胞表位标识方法,包括线性表位和形状表位的实验和计算方法. 它解决了开发疫苗和免疫疗法的挑战和资源.

科学领域:

  • 免疫学 免疫学 免疫学
  • 生物信息学是一种生物信息学.
  • 疫苗开发 疫苗开发

背景情况:

  • B细胞表位 (BCE) 对于设计疫苗和免疫疗法至关重要.
  • 现有的审查缺乏对ECB识别方法的全面概述.
  • 在四十年来,在西元前的形预测已经取得了显著的进步.

研究的目的:

  • 为B细胞表位标识的所有方面提供系统和全面的审查.
  • 涵盖实验技术,历史视角和计算方法用于 BCE 预测.
  • 讨论识别线性和构造性表征的挑战.

主要方法:

  • 对用于表位标识的实验技术的系统审查.
  • 对验证的欧洲央行信息的历史资源的审查.
  • 对预测形态和线性 BCE 的 in silico 方法进行了广泛的审查.
  • 讨论在表位标识方面的挑战.

主要成果:

  • 详细概述实验方法,它们的局限性和挑战.
  • 关于欧洲央行历史数据和资源的总结.
  • 对预测形态和线性ECB的计算工具进行全面的审查.
关键词:
预测B细胞表位预测类特定的表征物.形状的B细胞表皮图.数据库就是数据库.深度学习是一种深度学习.线性B细胞表皮图机器学习是机器学习.

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Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
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Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

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Last Updated: Jul 16, 2025

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
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Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

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Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
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Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

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  • 在表位图绘制中识别总体挑战.

    • 结论:

    • 对BCE识别的全面理解对于推进疫苗和免疫疗法开发至关重要.
    • 本综述巩固了关于实验和计算方法的知识,解决了当前的局限性.
    • 需要进一步的研究和开发强大的预测工具来克服识别挑战.