来自电机电路门的抑制反在Caenorhabditis elegans中的机械传感处理
Sandeep Kumar1, Anuj K Sharma2, Andrew Tran1
1Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, United States of America.
PLoS biology
|September 21, 2023
概括
C. elegans 虫在转动时抑制触摸引起的反转. 这可以通过从旋转神经元 (SAA,RIV,SMB) 到机械感知通路的抑制反来实现,在运动过程中阻断反应.
科学领域:
- 神经科学是一个神经科学.
- 动物行为 动物行为
- 计算生物学 计算生物学
背景情况:
- 动物将感官信息与行为上下文进行整合,以获得适当的反应.
- 感觉线索的神经处理是通过运动动态调节的.
- 了解神经回路如何实现这种集成是一个关键的挑战.
研究的目的:
- 调查在C. elegans.转动过程中抑制机械感官反应的基础的神经机制.
- 根据运动背景确定参与调节感官处理的特定神经元和途径.
- 阐明抑制反如何塑造行为决策.
主要方法:
- 由特定行为 (转向) 引发的高通量光遗传性扰动.
- 对Caenorhabditis elegans的行为分析.
- 神经电路映射和功能询问.
主要成果:
- 转动关联神经元 (SAA,RIV,SMB) 提供抑制反,抑制转动期间机械感官唤起的反转.
- 转动时机械感应神经元或特定内神经元的激活不太可能引起相比向前运动的反转.
- 在旋转过程中抑制SAA,RIV和SMB神经元恢复了对机械感官刺激的逆转反应.
- 前运动内部神经元 AVA 不管运动状态如何,都会引起反转,这表明它位于抑制门的下游.
结论:
- C. elegans利用来自运动回路的抑制反来快速调节感官处理.
- 这种运动到感官关门机制允许依赖上下文的行为反应.
- 这些发现可能解释了生物体内的感官区域中广泛存在的运动相关神经活动.
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