菌根性角膜炎:一种新型植物病原体,引起人类感染
Hua-Tao Xie1, Shi-Ming Cheng2, Jia-Song Wang1
1Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; and.
Cornea
|September 21, 2023
概括
这项研究报告了第一个由Botryosphaeria dothidea引起的真菌性角膜炎病例. 下一代测序确定了真菌,它对抗真菌治疗做出了反应,尽管出现了角膜穿孔.
科学领域:
- 眼科医生 眼科 眼科
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
背景情况:
- 菌性角膜炎是一种严重的眼睛感染.
- 植物病原体 (Botryosphaeria dothidea) 是一种植物病原体,以前不知道会引起人类感染.
研究的目的:
- 报告第一个由Botryosphaeria dothidea引起的真菌性角膜炎病例.
- 突出下一代测序 (NGS) 在识别真菌病原体方面的诊断实用性.
主要方法:
- 诊断涉及体内共聚焦显微镜 (IVCM),微生物培养和NGS.
- 治疗包括局部和全身沃里科纳和安福特里辛B.
- 由于角膜穿孔,进行了带有羊水膜和结膜足骨移植的手术干预.
主要成果:
- NGS确定了Botryosphaeria dothidea作为致病剂,而培养则失败了.
- 患者接受了沃里康纳和安福特里辛B的治疗.
- 尽管最初的制,角膜穿孔发生,需要手术修复.
结论:
- 植物菌 (Botryosphaeria dothidea) 是一种新发现的真菌性角质炎的原因.
- 鉴定到的B.dothidea菌株对沃里康纳和安福特里治疗有反应.
- NGS是诊断菌诱导的角膜炎的一个有价值的工具.
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