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在ALS中,体感皮层的刺激性增加:一项SEP恢复功能的研究

Bülent Cengiz¹, Özlem Kurtkaya Koçak², Tuğba Erdoğan³

¹Department of Neurology, Faculty of Medicine, Gazi University, Ankara, Turkey; Department of Neurology, Section of Clinical Neurophysiology, Faculty of Medicine, Gazi University, Ankara, Turkey; Neuroscience and Neurotechnology Center of Excellence, Ankara, Turkey.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

|September 21, 2023

概括

肌缩侧面硬化症 (ALS) 患者表现出体感皮层刺激性增加. 这种感官处理障碍与ALS的肺功能和运动强度降低相关.

科学领域:

神经科学是一个神经科学.
神经学神经学
临床研究临床研究

背景情况:

肌缩侧面硬化症 (ALS) 的特征是运动和感觉皮层的神经元损失.
之前的研究表明,在ALS中, afferent抑制受损,这表明感官皮层参与.

研究的目的:

为了研究ALS患者体感皮层激发能力的变化.
为了将体感皮层刺激性与ALS的临床和电生理学测量相关联.

主要方法:

在ALS患者和健康对照中使用了一种配对脉冲体感觉唤起潜力 (SEP) 范式,具有不同的刺激间隔 (ISI).
计算了S2/S1振幅比作为体感皮层刺激性的度量.
在ALS组中评估静止电机值 (RMT).

主要成果:

在所有ISI中,ALS患者的S2/S1比率升高,表明体感皮质刺激性增加.
减少感官抑制与强迫生命能力,MRC总分和中枢神经化合物肌肉动作潜力的幅度负相关.
在降低抑制和Penn上部运动神经元得分和外围神经传导速度之间发现了积极的关联;与RMT没有相关性.

结论:

在患有ALS的个体中,体感皮层刺激性显著增加.
这种高兴度与疾病进展的关键临床指标有关,包括肺功能减弱和运动强度下降.
需要进一步的研究来确定这是否与运动皮层刺激性增加有关.

关键词:

肌缩性侧面硬化症 (AMLS) 是一种疾病.皮层刺激性皮层刺激性人体感官皮层体感官皮层.身体感官唤起潜在的潜力.

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Somatosensation

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The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.