多发性硬化症的腹手术结果:与维生素D和慢性疼痛综合征的相互作用
Alexandra Balshi1, Emma Saart2, John Dempsey1
1Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Multiple sclerosis and related disorders
|September 21, 2023
概括
多发性硬化症 (MS) 患者的腹腔外科手术改善了维生素D水平,并降低了BMI. 失败的减肥与慢性疼痛和 gabapentin 使用有关.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 代谢手术 代谢手术
背景情况:
- 肥胖和维生素D不足与多发性硬化症 (MS) 的不良结果有关.
- 腹腔外科手术对MS患者是安全的,但可以降低维生素D水平一般.
- 这项研究研究了减肥手术对MS中维生素D的影响.
研究的目的:
- 评估减肥手术对MS患者维生素D水平的影响.
- 确定MS中手术后低于最佳体重减轻的预测因素.
主要方法:
- 对接受减肥手术的多发性硬化症患者 (2001-2023) 的回顾性分析.
- 使用威尔科克森签名的等级测试比较手术前和后的BMI,EDSS,T25FW和维生素D.
主要成果:
- 手术后显著降低BMI (18.4%的体重减轻) 和增加维生素D水平 (平均23 ng/mL).
- 扩展残疾状况尺度 (EDSS) 或定时25英尺步行 (T25FW) 没有显著变化.
- 四名患者的BMI下降率为<5%,与慢性疼痛和 gabapentin相关.
结论:
- 腹腔外科手术可以导致MS患者的健康维生素D水平.
- 减肥的成功可能受到慢性疼痛和药物等因素的影响.
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