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英格兰严重和耐治疗抑郁症的经验:一种混合方法研究

Cicely Kerr¹, Tom Denee¹, Sally-Anne Vincent²

¹Janssen-Cilag Ltd., High Wycombe, UK.

Acta psychologica

|September 21, 2023

概括

重度抑郁症 (MDD) 和耐治疗抑郁症 (TRD) 显著影响生活和工作质量. 标准测量可能会低估这些影响,强调需要更广泛的临床考虑.

科学领域:

精神病学是一个精神病学.
心理健康研究心理健康研究
混合方法研究研究混合方法研究

背景情况:

重度抑郁症 (MDD) 是一种普遍的,反复复发的疾病,会影响人们的幸福感,并导致大量的医疗费用.
耐治疗抑郁症 (TRD) 在患者体验和治疗疗效方面提出了独特的挑战.
混合方法研究提供了一种全面的方法来理解抑郁症的多面性质.

研究的目的:

调查患有症状性MDD,症状性TRD和缓解期TRD的个体的经历.
为了比较MDD和TRD对与健康相关的生活质量 (HRQoL) 和工作生产力的影响.
探索当前评估工具在捕捉抑郁症状影响的全谱方面的局限性.

主要方法:

一项混合方法研究,涉及来自英国临床场所的148名成年人.
量化指标包括症状严重程度 (PHQ-9),HRQoL (EQ-5D-5L,WHOQOL-BREF) 和工作障碍 (WPAI:D).
从26次采访中获得的定性数据被专题分析并与定量发现相结合.

主要成果:

定性数据显示,由于心理,情感和身体困难,对日常活动,社会参与和职业生涯产生了重大影响.
低HRQoL (WHOQOL-BREF) 评分与疲劳,缺乏动力和注意力不集中有关,影响工作表现.
针对TRD的具体主题包括应对困难,自我护理挑战,服务不满和治疗悲观.
在定性发现和EQ-5D-5L之间观察到一个显著的断开,只有19%的HRQoL代码映射.

结论:

像EQ-5D-5L和WPAI:D这样的标准化措施可能会低估MDD和TRD患者的HRQoL和工作影响.
与患有MDD的人相比,患有TRD的人经历了更大的痛苦.
临床管理应整合对抑郁症更广泛影响和环境因素的整体理解.

关键词:

与健康相关的生活质量.大型抑郁症主要是抑郁症.混合方法混合方法.有关质量的质量.治疗耐药性抑郁症的治疗方法工作障碍工作障碍

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