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选择的β-葡萄糖通过改善人类巨细胞的抗菌活性作为免疫训练剂:试点研究

Clara Braian¹, Lovisa Karlsson², Jyotirmoy Das^3,4

¹Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Faculty of Medicine, Linköping University, Linköping, Sweden, clara.braian@liu.se.

Journal of innate immunity

|September 21, 2023

概括

某些β-葡萄糖可以训练先天性免疫细胞,增强宿主对抗Mycobacterium结核病感染的反应. 这种免疫训练显示出开发新的结核病治疗方法的前景.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
生物化学生物化学

背景情况:

贝塔葡萄糖,被巨细胞识别为非自我,是各种微生物和植物的组成部分.
训练有素的免疫力是先天免疫细胞的表观遗传重编程,增强了宿主对二次感染的防御能力.
结核菌菌感染仍然是一个重大的全球卫生挑战,需要新的治疗策略.

关键词:

贝塔葡萄糖是一种β-glucan.巨细胞是一个巨细胞.结核病菌菌菌的结核病菌的结核病菌.中性粒细胞中性粒细胞.训练有素的免疫力

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