调节性T细胞需要IL6受体α信号来控制骨肌肉功能和再生
Maike Becker1, Sini S Joseph2, Francisco Garcia-Carrizo3
1Research Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Munich-Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany.
Cell metabolism
|September 21, 2023
概括
运动可以增强肌肉调节T细胞 (Tregs),这对组织修复至关重要. 阻止IL6Rα会损害Treg功能和肌肉再生,突出显示IL-6信号传递.
科学领域:
- 免疫学 免疫学 免疫学
- 肌肉生物学 肌肉生物学
- 再生医学是一种再生医学.
背景情况:
- 居住在肌肉中的调节性T细胞 (Tregs) 对于组织平衡和修复至关重要.
- 将Treg功能与肌肉再生联系在一起的分子机制尚未完全理解.
研究的目的:
- 研究IL-6受体α (IL6Rα) 在肌肉Treg功能和肌肉再生中的作用.
- 探索运动对肌肉Treg表型和功能的影响.
主要方法:
- 利用IL6Rα缺乏的T细胞淘汰 (TKO) 小鼠,运动干预,肉病模型和肌肉损伤模型.
- 评估了Treg功能,卫星细胞种群和纤维基原始细胞.
- 研究了在野生型 (WT) 小鼠中药理性IL6R阻断的影响.
主要成果:
- 运动诱导的稳定,高功能肌肉Tregs与增加的安菲瑞古林 (Areg),EGFR和ST2表达.
- 在IL6Rα TKO小鼠中,Treg功能降低,肌肉再生受损,在肉病模型中肌肉质量下降加剧.
- 在IL6RαTKO小鼠中,Treg功能增益恢复了肌肉修复.
- 药理上IL6R阻塞模仿了IL6RαTKO小鼠观察到的肌肉功能缺陷.
结论:
- IL6Rα信号传递对于维持肌肉Treg功能和促进有效的肌肉再生至关重要.
- 向IL6Rα代表了针对肌肉疾病和与年龄有关的肌肉衰退的潜在治疗策略.
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