昆徐安比配方通过AhR/ROS/ERK通路抑制了佐[a]烯诱导的恶化喘气道粘液分泌
Bo-Han Wang1, Ling-Ling Tang2, Xian-Hong Sun1
1Affiliated Hospital of Nanjing University of Chinese Medicine/ Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, Jiangsu Province, China.
Journal of ethnopharmacology
|September 21, 2023
概括
昆峰比配方 (QFXBF) 有效地降低了气道粘液分泌在喘加剧空气污染物,如[a]烯 (BaP). 这种传统配方通过抑制酸受体 (AhR) /反应性氧物种 (ROS) /细胞外信号调节激酶 (ERK) 信号通路而起作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 呼吸系统医学 呼吸系统医学
- 环境健康 环境健康
背景情况:
- 空气污染通过增加气道粘液分泌而加剧喘.
- 曲徐安比配方 (QFXBF) 是一种用于治疗喘的中国传统药物.
- QFXBF对空气污染引起的粘液高分泌的影响尚未得到充分证实.
研究的目的:
- 为了研究QFXBF在减轻粘液分泌中的疗效,在子[a]皮林 (BaP) 加重的喘的小鼠模型中.
- 阐明QFXBF对BaP诱导的气道粘液产生作用的潜在机制.
主要方法:
- 通过使用卵胺 (OVA) 和BaP联合暴露,建立了一种恶化喘的小鼠模型.
- 评估肺功能 (Penh),血清IgE和肺组织病理学.
- 利用暴露于BaP的16HBE细胞来研究QFXBF对MUC5AC表达,ROS产生以及酸受体 (AhR) /ERK信号通路的影响.
- 使用特定抑制剂 (SR1,NAC,U0126) 来探测信号级联.
主要成果:
- 在暴露于BaP的小鼠和细胞中,QFXBF显著改善了喘症状,减少了MUC5AC的表达,并抑制了ROS的产生.
- BaP暴露增加了AhR表达和ERK酸化,而QFXBF可以逆转这些表达和酸化.
- 抑制AhR,ROS和ERK信号通路的抑制剂降低了BaP诱导的MUC5AC表达.
- QFXBF证明了AhR/ROS/ERK通路的调节,导致粘液分泌减少.
结论:
- 在BaP诱导恶化的喘的小鼠模型中,QFXBF有效地改善了气道粘液分泌.
- 该机制涉及AhR/ROS/ERK信号通路的抑制.
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