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功能性超声波揭示了MRI声学噪声对大脑功能的影响

Keigo Hikishima¹, Tomokazu Tsurugizawa², Kazumi Kasahara²

¹Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-2-1 Namiki, Tsukuba, Ibaraki 305-8564, Japan; Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinwa 904-0495, Japan.

|September 21, 2023

概括

大声的扫描仪噪声显著改变了小鼠的静止状态功能连接 (FC),影响了大脑网络对抗性. 功能性超声波 (fUS) 显示了这些效应,这表明噪声水平对于解释静止状态fMRI (fMRI) 数据至关重要.

科学领域:

神经成像是一种神经成像.
神经科学是一个神经科学.
生物物理学的生物物理.

背景情况:

来自功能磁共振成像 (fMRI) 扫描仪的声噪声可能会影响静止状态功能连接 (FC) 测量.
这种声学噪声对静止状态FC的确切影响仍然不完全理解.
功能性超声波 (fUS) 提供了一个替代的神经成像方法,测量相对脑血量 (rCBV) 没有可听的噪音.

研究的目的:

为了研究不同音响噪声水平对静止状态功能连接 (rsfUS) 的影响,在醒着的小鼠中使用fUS.
在类似的噪音条件下,将fUS发现与静止状态fMRI (rsfMRI) 数据进行比较.
阐明声学噪声在大脑网络对抗中的作用,特别是默认模式网络 (DMN) 和任务积极感应运动网络 (TSN).

主要方法:

休息状态fUS (rsfUS) 在静音,80dB和110dB的声噪条件下在清醒的小鼠中进行.
休息状态fMRI (rsfMRI) 使用11.7特斯拉扫描仪进行比较.
使用fUS进行了与事件相关的听觉刺激实验,以评估大脑区域对噪音的反应.

主要成果:

增加的声音噪声水平 (80 dB,110 dB) 显著降低了rsfUS.rsfUS中后膜干细胞和听觉皮层之间的FC.
观察到,随着噪音水平的上升,下肢皮层 (DMN) 和运动皮层 (TSN) 之间的FC抗相关性显著增加.
fUS听觉刺激显示了听觉皮层中强大的rCBV变化和运动皮层中负的rCBV变化,与静止状态实验中观察到的网络变化一致.
在较大噪声条件下,FC模式显示rsfUS和rsfMRI之间的一致性增加.

结论:

声噪声水平明显影响静止状态的功能连接和大脑网络对抗.
fUS是研究声学噪声对大脑活动影响的可行工具,补充了rsfMRI发现.
在解释 rsfMRI 数据时,对声噪声的仔细考虑至关重要,特别是关于 DMN-TSN 反相关性,这是神经功能障碍的潜在生物标志物.

关键词:

声学噪声声学噪声是一种声学噪声.大脑活动大脑活动功能性核磁共振成像 (MRI) 是一种功能性核磁共振成像.功能连接性的功能连接性.功能性超声波是指功能性超声波.休息状态休息状态

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