在侵袭性叶状乳腺癌中,状淋巴结转移的预后值
M Deberti1, C Goupille2, F Arbion3
1Department of Gynaecology, Centre Hospitalier Régional Universitaire de Tours, Hôpital Bretonneau, 2 boulevard Tonnellé 37044 Tours, France; François-Rabelais University, Tours, France.
Journal of gynecology obstetrics and human reproduction
|September 21, 2023
概括
淋巴结的参与显著影响侵袭性叶状腺癌患者的生存率. 淋巴结比 (LNR) 是整体存活率和远程无转移存活率的可靠预测指标.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 乳腺癌研究研究 乳腺癌研究
背景情况:
- 状淋巴结状况是乳腺癌的关键预后因素,特别是侵入性导管癌.
- 关于淋巴结参与侵袭性叶状腺癌 (ILC) 的预后意义的数据有限.
研究的目的:
- 评估淋巴结干扰对ILC患者整体存活率 (OS) 和远程无转移存活率 (DMFS) 的预后影响.
- 评估淋巴结比率 (LNR) 在ILC预测结果中的作用.
主要方法:
- 在2007年至2018年期间接受治疗的ILC患者的一项单心观察性研究.
- 基于LNR类别的OS和DMFS分析:低风险 (≤0.2),中等风险 (>0.2≤0.65) 和高风险 (>0.65).
主要成果:
- 在LNR组中观察到OS和DMFS的显著差异 (p < 0.0001).
- 五年OS率在94% (N0) 到58.5% (高风险LNR) 之间.
- 五年DMFS的发病率从98.2% (N0) 到60.3% (高风险LNR) 之间.
- 多变量分析确定了LNR风险类,年龄,组织学类型和临床炎症作为OS的独立因素.
- 临床炎症,LVSI和LNR风险类是DMFS的独立因素.
结论:
- 淋巴结的参与,用LNR量化,显著影响ILC患者的存活率.
- 在ILC中,LNR作为可靠的预后标记,用于预测OS和DMFS.
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