聚乙烯微塑料暴露对血管有毒影响
Jianlong Yan1, Yanbin Pan2, Junbo He1
1Department of Cardiology, Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Center, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China.
The Science of the total environment
|September 21, 2023
概括
聚烯微塑料 (PSMP) 与人类的血管化 (VC) 有关,并且可以在老鼠中诱导VC. 暴露于PSMPs还会破坏肠道微生物群和肠道屏障功能,导致心血管疾病风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 心血管医学 心血管医学
背景情况:
- 微塑料污染,特别是来自聚乙烯微塑料 (PSMPs) 的污染,是全球关注的问题.
- 虽然PSMP的毒性在各种器官中得到研究,但其对血管毒性的影响仍然不太清楚.
- 血管化 (VC) 是心血管疾病的重要危险因素.
研究的目的:
- 为了研究微塑料 (MPs) 的血管毒性.
- 探索人类便中的MP水平与胸前大动脉化之间的关联.
- 检查PSMP暴露对VC,肠道微生物群和大鼠肠道健康的影响.
主要方法:
- 分析了7种聚合物类型的人类便样本,比较了有和没有胸前大动脉化的患者.
- 在MP丰度 (总,聚烯,聚烯) 和VC分数之间的相关性分析.
- 动物研究暴露大鼠PSMPs,评估VC,肠道微生物组成,肠道炎症和屏障功能.
主要成果:
- 患有VC的患者在便中总MP,聚烯 (PP) 和聚烯 (PS) 的水平较高.
- 在总MP,PP和PS的VC分数和便丰度之间发现了显著的正相关性.
- 暴露于PSMP会在正常老鼠中诱导轻微的VC,在接受VDN治疗的老鼠中诱导加重的VC,以及肠道失调和肠道损伤.
结论:
- 人类接触微塑料,特别是聚钢,与血管化有关.
- 通过诱导血管化和破坏肠道平衡,PSMP暴露对心血管健康构成风险.
- 这项研究为评估与微塑料暴露相关的心血管风险提供了基础.
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