抑郁和焦虑障碍的风险根据长期的血糖变化
Manjae Kwon1, Myeongjee Lee2, Eun Hwa Kim2
1Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Journal of affective disorders
|September 21, 2023
概括
高血糖变化和持续的高血糖与增加的抑郁和焦虑障碍有关. 这项研究强调了监测血糖波动对心理健康的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 低血糖控制与精神症状有关.
- 有限的研究存在于血糖变化 (GV) 和抑郁/焦虑.
- 这项研究调查了GV,禁食血葡萄糖 (FPG) 趋势和这些疾病之间的联系.
研究的目的:
- 为了检查血糖变化 (GV) 与抑郁和焦虑障碍之间的关联.
- 探索禁食血葡萄糖 (FPG) 趋势与这些心理健康状况之间的关系.
主要方法:
- 对一个大型的国家医疗保险数据库 (2002-2013) 的分析,共有151,814名参与者.
- 使用独立于平均值的变化 (VIM) 来测量访问到访问的FPG变化.
- 利用Kaplan-Meier,Cox比例危险和轨迹分析来评估关联和趋势.
主要成果:
- 在FPG-VIM的最高四分位数中,抑郁和焦虑的发病率增加.
- 对抑郁症和焦虑症的调整后危险比分分别为1.09和1.08.
- 持续高血糖与1.43倍的抑郁症风险增加相关.
结论:
- 高血糖变化 (GV) 与更高的抑郁和焦虑障碍发病率有关.
- 通过FPG趋势确定的持续性高血糖症显著增加了抑郁症的风险.
- 研究结果表明,监测葡萄糖的变化可能对心理健康很重要.
相关概念视频
Stress and Mental Health
176
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
176
Psychoneuroimmunology: Diabetes and Cancer
44
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
44
Human Genetics
601
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
601
Overview of Carbohydrate Metabolism
1.1K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.1K
Depressive Disorders: Etiology
114
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
114
Long-term Depression
2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.6K


