延迟带紧对红细胞与免疫接种的影响:一项回顾性队列研究
Alexane Tournier1, Louise Ghesquiere2, Julien Labreuche3
1Department of Obstetrics, Centre Hospitalier Universitaire de Lille, Lille, France (Drs Tournier, Ghesquiere, Houfflin-Debarge, and Garabedian).
American journal of obstetrics & gynecology MFM
|September 21, 2023
概括
在非免疫新生儿中,延迟带紧 (DCC) 增加了血红蛋白水平,并延迟了输血的需要,但没有增加黄风险. 这种做法无论免疫接种的严重程度如何都显示出好处.
科学领域:
- 新生儿医学 新生儿医学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 延迟带紧 (DCC) 对新生儿有好处,但对非免疫婴儿没有充分研究.
- 红细胞合免疫对新生儿构成风险,需要谨慎管理.
研究的目的:
- 评估新生儿中DCC的优势和风险,并与红细胞共免疫.
- 为了在这个特定的人群中比较即时和延迟的带紧之间的结果.
主要方法:
- 法国第三级护理中心的回顾性比较队列研究 (2003-2018).
- 包括224个单独的新生儿,确认了母亲的红细胞与免疫接种.
- 立即 (n=125) 与延迟 (n=99) 的绳索紧的结果进行比较.
主要成果:
- 出生时血红蛋白水平较高,患有DCC (平均差异为1.7g/dL).
- 延迟时间到初始输血/交换输血8天与DCC.
- 在严重的DCC (OR 0.36) 异免疫病例中减少了交换输血率.
- 输血需要,胆红素水平或光疗持续时间没有显著差异.
结论:
- 延迟带紧对非免疫新生儿有好处,改善血红蛋白和延迟输血.
- 在这个人群中,DCC不会增加黄的风险.
- DCC的好处在不同程度的免疫接种中得到观察.
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