抗万科胺素耐药肠球菌感染的流行病学和结果:系统性审查和元分析
V M Eichel1, K Last2, C Brühwasser3
1Heidelberg University Hospital, Center for Infectious Diseases, Section of Hospital and Environmental Hygiene, Heidelberg, Germany.
The Journal of hospital infection
|September 21, 2023
概括
抗万科素肠球菌 (VRE) 感染是一个重要的医疗保健问题. 这项研究发现,不论肠球菌种类,万科米辛耐药性都与死亡率的增加有关,这凸显了未来研究中标准化报告的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 医疗保健相关的感染
背景情况:
- 抗菌素的肠球菌 (VRE) 是越来越多的医院感染的原因.
- 目前关于VRE流行病学和患者结局的知识仍然分散.
- 需要综合最近关于医疗机构VRE感染的全球数据.
研究的目的:
- 总结最近关于VRE感染流行病学和结果的研究.
- 分析与VRE相关的发病率,感染率,死亡率,停留时间和医疗费用.
- 进行对VRE血流感染死亡率的元分析.
主要方法:
- 在MEDLINE/PubMed,Cochrane图书馆和科学网络的系统文献搜索.
- 包括住院患者的VRE体和体的观察性研究 (2014年1月 - 2020年12月).
- 对死亡率数据进行的元分析 (PROSPERO CRD42020146389).
主要成果:
- 包括57项研究;证据质量中等至低.
- 报告VRE发病率是罕见的和异质的;感染率差异很大 (1-55%).
- 分析显示,VRE体BSI的死亡率高于VSE体BSI的死亡率 (RR 1.46). 在VRE faecium和VRE faecalis BSIs之间没有显著的差异.
- 与E. faecalisBSI相比,E. faeciumBSI的停留时间更长.
结论:
- 不管是哪种VRE物种,万科米辛耐药性可能与死亡率的增加有关.
- 结果报告,成本数据和微生物学方法中存在显著的标准化缺失.
- 未来的研究需要标准化报告,以更好地了解VRE负担和影响.
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