低收入和中等收入国家的低最佳妊娠体重增加和新生儿结果:个人参与者数据的元分析
Nandita Perumal1,2, Dongqing Wang3, Anne Marie Darling2
1Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.
概括
超出推范围的孕期体重增加 (GWG) 与低收入和中等收入国家的新生儿不良结果有关. 促进最佳GWG的干预措施可以降低风险,但为定制建议需要进一步研究.
科学领域:
- 孕产妇和儿童的健康
- 围产期流行病学 围产期流行病学
- 全球健康 全球健康
背景情况:
- 孕期体重增加 (GWG) 建议主要基于高收入国家数据.
- 在低收入和中等收入国家 (LMICs) 中,GWG充分性对新生儿结局的影响需要进一步调查.
研究的目的:
- 在LMICs中估计妊娠体重增加 (GWG) 和新生儿结局之间的关联.
- 分析母亲年龄和怀孕前的BMI对这些关联的影响.
主要方法:
- 来自24个LMIC的53项前性怀孕研究的个人参与者数据元分析.
- 根据医学研究所和INTERGROWTH-21st标准评估了GWG的充分性.
- 使用随机效应元分析模型,将针对混因素调整的特定研究估计汇总起来.
主要成果:
- 严重不足的GWG与低出生体重,妊娠年龄小/短和小头症的风险增加有关.
- 过度的GWG与早产的风险更高,对于妊娠年龄来说很大,以及宏观性.
- 母亲年龄和怀孕前的BMI改变了GWG充足度和新生儿结局之间的关联.
结论:
- 不充分和过度GWG都与LMIC中新生儿不良后果的风险增加有关.
- 促进最佳GWG的干预措施可以减少新生儿不良后果的负担.
- 需要进行进一步的研究,以确定最优的GWG范围,具体适用于LMIC人口.
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