在极早出生的成年人中,对运动的心肺反应
Jacques Delfrate1,2,3, Camille Girard-Bock1,3, Daniel Curnier1,4
1CHU Sainte-Justine Research Centre, University of Montreal, Montreal, QC, Canada.
The European respiratory journal
|September 21, 2023
概括
非常早产的年轻人由于外围限制而减少了运动能力,而不是心脏问题. 需要进一步的研究来了解运动期间肌肉的氧气使用情况.
科学领域:
- 心肺运动生理学心肺运动生理学
- 新生儿医学 新生儿医学
- 成人呼吸系统和重症监护医学
背景情况:
- 非常早产的年轻人表现出改变了对运动的心肺反应.
- 支气管肺功能障碍 (BPD) 是极度早产婴儿的常见并发症,可能会影响长期运动能力.
研究的目的:
- 为了比较心肺反应在有氧运动在成年人出生非常早产与期内对照.
- 调查支气管肺功能障碍 (BPD) 对该人口运动能力的特定影响.
主要方法:
- 用阻抗心脏图进行心肺运动测试,对71名出生在妊娠30周以下的成年人 (24名患有BPD) 和73名术语对照 (18-29岁) 进行了测试.
- 使用线性回归分析了峰值氧气吸收 (VO2) 和呼吸/心血管反应的群体差异.
主要成果:
- 与对照组相比,早产期参与者显示VO2峰值降低.
- 患有BPD的个体的峰值工作率较低,峰值循环功率降低.
- 在早产个体中,氧气吸收和工作速度 (ΔVO2/ΔWR) 之间的关系有所减少,这表明外围限制.
结论:
- 在非常早产的成年人中,运动限制似乎源于外围因素,特别是氧气吸收效率和循环功率降低,而不是心脏输出.
- 建议进一步研究肌的输液和运动期间的氧气利用,以阐明这些机制.
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