使用有机体的下一代癌症建模
Jillian R Love1, Wouter R Karthaus2
1Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, 1015 Lausanne, Switzerland.
Cold Spring Harbor perspectives in medicine
|September 21, 2023
概括
机体技术,即3D长期初级细胞培养,正在彻底改变癌症研究. 这些模型准确地模仿了患者的瘤,推进了个性化医学和癌症的基本发现.
科学领域:
- 生物技术是生物技术.
- 癌症研究 癌症研究
- 细胞生物学 细胞生物学
背景情况:
- 器官技术已经成为当代癌症研究的关键工具.
- 器官体是三维 (3D) 初级细胞培养物,通常是上皮细胞,在专门的矩阵和介质中培养.
- 它们可以从各种各样的器官,癌症类型和瘤进化阶段,人类和小鼠组织中提取.
研究的目的:
- 讨论有机体培养技术的起源和发展.
- 探索有机素在癌症研究中的多方面的应用.
- 突出癌症器官的潜力,与其他癌症模型协同发挥临床转化作用.
主要方法:
- 建立长期的初级细胞培养.
- 在三维 (3D) 蛋白质矩阵内进行培养.
- 使用完全定义的培养媒介.
主要成果:
- 在体外 (in vitro) 中,有机器人总结了患者特定的基因组和表型,具有高保真度.
- 这些模型为个性化医疗方法提供了一个强大的平台.
- 器官体表现出显著的易受实验操纵.
结论:
- 器官技术为基础癌症研究提供了一种强大而通用的工具.
- 癌症器官对推进个性化癌症治疗策略具有巨大的前景.
- 癌症有机体与其他模型的协同集成可以加速将发现转化为临床解决方案.
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