在接受非心脏手术的老年患者中开发和验证诱导后低血压预测模型的协议:前性队列研究
Jing-Hui Hu1,2, Ning Xu1,2, Zhen Bian1,2
1Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
BMJ open
|September 21, 2023
概括
这项研究开发了一种预测模型,用于老年手术患者的诱导后低血压 (PIH). 该模型旨在识别患有PIH风险的患者,以便采取预防措施.
科学领域:
- 麻醉学 麻醉学
- 老年医学 老年医学
- 临床预测建模临床预测建模
背景情况:
- 诱导后低血压 (PIH) 是老年手术患者经常出现的并发症.
- PIH与术后发病率和死亡率的增加有关.
- 早期识别风险患者对于实施预防策略至关重要.
研究的目的:
- 开发和验证一种用于诱导后低血压 (PIH) 的预测模型.
- 为了识别患有PIH风险的接受选择性非心脏手术的老年患者.
- 促进对PIH的及时预防性干预.
主要方法:
- 总共有938名老年手术患者被纳入模型开发,内部验证和时间验证.
- 最小绝对收缩和选择运算符 (LASSO) 回归和多变量后勤回归用于模型开发.
- 引导和时间验证被用于评估模型性能,以及歧视,校准和决策曲线分析.
主要成果:
- 该研究开发并验证了一种PIH预测模型,使用938名老年手术患者的数据.
- 用歧视,校准和决策曲线分析来评估模型性能.
- 结果将通过名图和基于网络的风险计算器进行临床实用性的展示.
结论:
- 经过验证的PIH预测模型可以帮助识别有风险的老年手术患者.
- 该工具可以支持实施针对PIH的有针对性的预防措施.
- 该模型的临床实用性将通过名图和基于网络的计算器来增强.
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