高海拔地区中风的患病率和风险因素:系统性审查和元分析
Bo Zheng1, Yuding Luo1,2, Yan Li1
1Department of Neurology, Ya'an Peoples Hospital, Ya'an, People's Republic of China.
BMJ open
|September 21, 2023
概括
高海拔地区中风的发病率为0.5%,临床样本和美洲的发病率更高. 年龄,性别,高血压和肥胖是关键的危险因素.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 环境医学 环境医学
背景情况:
- 高海拔环境带来了独特的生理挑战.
- 脑卒中是一个重大的全球健康问题,其患病率可能受到海拔高度等环境因素的影响.
- 了解高海拔地区中风流行病学对于有针对性的公共卫生干预至关重要.
研究的目的:
- 系统地审查和对高海拔地区人群中风的患病率和风险因素进行元分析.
- 识别高海拔地区中风发病率的地理和人口变化.
主要方法:
- 系统审查和对2023年6月之前发表的研究进行元分析.
- 在主要数据库 (PubMed,科学网,Embase等) 进行了搜索. ) 的情况.
- 纽卡斯尔-太华尺度评估了纳入研究中的偏差风险.
主要成果:
- 分析了17项涉及超过850万名参与者的研究,这些研究来自1500米-5000米的高度.
- 在高海拔地区的综合中风患病率为0.5% (95% CI 0.3%-7%),在临床样本 (1.2%) 中高于一般人口 (0.3%).
- 患病率在地理位置上有所不同 (欧亚洲:0.3%;美洲:0.8%) 并与年龄,性别,高血压和肥胖有关.
结论:
- 在高海拔地区的中风患病率估计为0.5%,具有显著的区域和采样差异.
- 年龄,性别,高血压和肥胖被证实是这些人群中风的重要危险因素.
- 这些发现强调需要高度特定的中风预防和管理策略.
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