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超声波在评估乳腺癌中新辅助化疗反应的价值
H F Lim1, A Sharma1, C Gallagher2
1Department of Radiology, Western General Hospital, Crewe Rd S, Edinburgh EH4 2XU, UK.
在新辅助化疗 (NAC) 期间对瘤大小变化的超声波测量可以预测病理完整反应 (pCR) 和残留癌症负担 (RCB) 指数. 较小的变化意味着更高的RCB类.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 新辅助化疗 (NAC) 是各种癌症的关键治疗方法.
- 准确评估NAC反应对于治疗分层和患者结果至关重要.
- 预测病理完整反应 (pCR) 和残留癌症负担 (RCB) 指数有助于评估治疗疗效.
研究的目的:
- 评估超声波在评估对NAC的反应中的实用性.
- 为了确定超声波是否可以预测残留癌症负担 (RCB) 指数.
- 用超声波评估病理完整反应 (pCR) 的预测.
主要方法:
- 追溯研究包括7年来417名患者.
- 从基线到终点,从基线到中期,以及从中期到终点的NAC指数损伤最长直径 (LD) 的变化分析.
- 使用后勤回归和有序后勤回归来评估LD变化与RCB类之间的关系.
主要成果:
- 在LD测量变化和RCB类之间观察到统计学上显著的负相关性.
- 较小的LD测量变化与较高的RCB类有关.
- 从基线到终点和从基线到中期化学疗法的LD测量的变化显著预测了pCR (p<0.05).
结论:
- 在超声波上减少LD测量是PCR和RCB等级的显著预测指标.
- 在化疗周期的开始,中期和结束时进行超声监测对于评估NAC反应非常有价值.
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