在使用非侵入性心脏输出监测器测量正常血压的孕妇中测量的第三季度母亲心血管功能参数的参考范围:基于前性PEACH队列研究数据的研究
Frederikke Lihme1, Saima Basit1, Lisa G Persson1
1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
BJOG : an international journal of obstetrics and gynaecology
|September 21, 2023
概括
确定了孕妇心脏输出,全身血管阻力和妊娠中风体积的新参考范围. 这些范围来自于超声波测量,有助于评估心脏功能和识别危险妊娠.
科学领域:
- 怀孕期间的心血管生理学
- 孕产妇和胎儿的医学
- 诊断超声波的应用 诊断超声波的应用
背景情况:
- 在怀孕期间确定心血管参数的正常生理范围对于监测母亲健康至关重要.
- 以前用于评估怀孕期间心脏功能的方法缺乏标准化的参考值,这阻碍了准确的临床解释.
研究的目的:
- 定义孕妇心脏输出,全身血管阻力和在怀孕第三个月的中风体积的参考范围.
- 验证使用超声波心脏输出监测器1A用于对这些心血管参数进行非侵入性评估.
主要方法:
- 分析了PEACH队列研究中405名正常血压孕妇 (18-45岁) 的前性数据.
- 用分数多项式的多层线性模型来建模心血管参数作为妊娠年龄 (28-40周) 的函数.
- 无条件和有条件的参考范围被生成,考虑到母亲的身高,年龄和平等.
主要成果:
- 心脏输出量和中风量在妊娠30-32周之间达到峰值,随后下降.
- 系统性血管抵抗在整个第三个三个月表现出越来越大的趋势.
- 为八种母体人口组合建立了参考范围,并为实际应用开发了一种临床计算器.
结论:
- 开发的参考范围允许使用超声波对心脏功能进行非侵入性临床评估.
- 这些范围有助于识别有心血管并发症风险的孕妇.
- 条件范围通过结合连续测量来增强监测,改善从正常趋势偏差的检测.
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