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在帕金森病中灰质结构的基于voxel的形态测量与磨损的帕金森病

Heng Zhai^1,2, Wenliang Fan^3,4, Yan Xiao^3,4

¹Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, No. 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong Province, China.

Brain imaging and behavior

|September 22, 2023

概括

与没有这种症状的帕金森病患者相比,经历磨损的帕金森病患者在皮质区域显示出显著的灰质缩. 这项研究使用基于voxel的形态测量来识别这些大脑变化.

科学领域:

神经成像是一种神经成像.
神经学神经学
大脑解剖学大脑解剖学

背景情况:

帕金森病 (PD) 是一种神经退行性疾病.
磨损 (WO) 是PD患者经历运动波动的常见并发症.
了解WO的神经生物学基础对于患者管理至关重要.

研究的目的:

为了研究灰质 (GM) 变化,帕金森病患者的磨损 (PD-WO) 与那些没有磨损 (PD-nWO) 和健康对照 (HCs) 相比.
确定受转基因缩影响的特定大脑区域,与PD的磨损现象相关.

主要方法:

使用基于voxel的形态测量 (VBM) 分析.
从48个PD-nWO,39个PD-WO和47个HC中获得了3D-T1加权的结构性MRI扫描.
统计参数映射 (SPM12) 用于分析灰色物质体积差异.

主要成果:

在所有三组中都观察到广泛的转基因变化.
与PD-nWO组相比,PD-WO组在额叶,叶,叶,舌环和下环中表现出显著的GM减少.
在PD-WO中缩的特定区域包括右中额头环,上额头环,前中心环,前环,上上环,后中心环,上环,中环,双边舌头环和下环.

结论:

帕金森病的磨损与特定皮质区域的显著灰质缩有关.
这些发现有助于理解PD中随着磨损的脑退化过程.
鉴定到的转基因变化可能成为磨损现象的潜在生物标志物.

关键词:

灰色的物质就是灰色的物质.帕金森氏症帕金森氏症基于voxel的形态测量方法磨损的消退 - 磨损的消退

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