通过母亲使用大麻暴露于大麻二醇:母乳养婴儿的预测
Cindy H T Yeung1, Kerri A Bertrand2, Brookie M Best2,3
1Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, ON, Canada.
Clinical pharmacokinetics
|September 22, 2023
概括
使用大麻 (CBD) 产品的母亲可能会将最小的CBD转移给母乳养的婴儿. 婴儿暴露水平明显低于儿童使用的治疗剂量,这表明风险低.
科学领域:
- 药理动力学和药物新陈代谢
- 儿科药理学 儿科药理学
- 人类牛奶分析
背景情况:
- 了解婴儿对大麻 (CBD) 的暴露对于评估潜在风险至关重要.
- 在母乳养期间,母亲使用CBD和含CBD的产品需要评估婴儿的暴露.
研究的目的:
- 为了预测母乳养的婴儿对大麻素 (CBD) 的暴露,这些婴儿的母亲使用CBD产品.
- 将模拟婴儿CBD暴露与儿童确定的治疗剂量进行比较.
主要方法:
- 利用现有的母乳样本和来自生物存储库的母乳管理数据.
- 采用了基于儿科生理学的药理动力学模型来模拟婴儿CBD剂量.
- 在母乳中分析的CBD度,根据母乳给药类型 (如食用,油).
主要成果:
- 模拟的婴儿剂量根据母亲的给药类型而异,联合/不或食用产品产生较低的度.
- 预测的婴儿暴露量远低于4至11岁儿童接受批准的最低治疗剂量.
- 发现曲线下的上面积比率很低,表明婴儿的系统性暴露最小.
结论:
- 预计通过母乳接触CBD的母乳养婴儿的暴露水平非常低.
- 需要对不良反应进行进一步研究,以充分阐明与婴儿CBD暴露相关的潜在风险.
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