对胎儿心室隔膜缺陷 (VSD) 的不良预后的风险因素分析
Wang Shan1, Xia Yuanqing1, Zhu Jing1
1Prenatal Diagnostic Center, International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
BMC pregnancy and childbirth
|September 22, 2023
概括
染色体异常显著增加了腹腔隔膜缺陷 (VSD) 发生和不良胎儿结果的风险. 大型VSD大小和周边膜位置进一步提高了这些风险.
科学领域:
- 遗传学 是一个遗传学.
- 心脏病学 心脏病学
- 产前诊断 在产前诊断
背景情况:
- 心室隔膜缺陷 (VSD) 是最常见的先天性心脏缺陷.
- 了解VSD病因及其相关风险因素对于产前咨询和管理至关重要.
研究的目的:
- 调查染色体异常与胎儿的VSD发生之间的关联.
- 评估VSD大小,位置和染色体异常对胎儿不良结果的影响.
主要方法:
- 对患有VSD的胎儿的回顾性分析和完整的随访数据.
- 在VSD胎儿上进行的常规型和染色体微阵列分析.
- 多变量后勤回归用于调整混因素并探索关联.
主要成果:
- 染色体异常是VSD发生的重要风险因素 (风险增加6.5倍).
- 染色体异常,周边膜性VSD部位和大缺陷大小 (>5毫米) 是导致胎儿不良后果的独立危险因素.
- 致病复制数变化 (CNVs) 和不确定的意义变化 (VUS) 分别增加了55.9倍和6.7倍的不良结果风险.
结论:
- 染色体异常,大VSD大小和周边膜位置是胎儿不良结果的关键风险因素.
- 染色体异常被认为是导致VSD发生的一个因素.
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