相关实验视频

Updated: Jul 16, 2025

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

前额叶皮层调节REM睡眠的过程

Jiso Hong¹, David E Lozano¹, Kevin T Beier²

¹Department of Neuroscience, Perelman School of Medicine, Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, PA, USA.

Nature neuroscience

|September 22, 2023

概括

中间前额叶皮层 (mPFC) 在小鼠中强烈促进快速眼动 (REM) 睡眠. 这个大脑区域通过皮质体-海马体通路调节REM睡眠及其相性事件.

科学领域:

神经科学是一个神经科学.
睡眠科学睡眠科学
皮层功能皮层功能

背景情况:

快速眼动 (REM) 睡眠表现出强烈的皮质活动,类似于清醒.
快速眼动睡眠的产生传统上归因于大脑干和下丘脑中的皮质下电路.
皮层神经元在启动REM睡眠中的潜在作用仍然在很大程度上未被探索.

研究的目的:

调查皮层神经元,特别是来自中部前额叶皮层 (mPFC) 的神经元,是否可以触发和调节REM睡眠.
为了阐明参与mPFC介导的REM睡眠控制的神经回路.
确定mPFC在调节REM睡眠期间阶段事件中的作用.

主要方法:

在小鼠中利用双向光遗传学操纵来激活或抑制mPFC神经元.
研究了mPFC神经元向横向下丘脑的投射.
采用成像来监测REM睡眠期间mPFC神经元的活动.
分析了脑电图 (EEG) 的动和眼睛运动密度.

主要成果:

发现激发性mPFC神经元强烈促进REM睡眠.
侧向下丘脑的mPFC投射调节REM睡眠及其阶段性事件.
阶段性事件的特点是加速的EEG θ 振荡和增加的眼睛运动密度.
大多数侧向下丘脑投射的mPFC神经元在REM睡眠期间最大限度地活跃,在阶段加速期间招募的子群体.

结论:

确定了一种新的皮层-海马体电路,用于对REM睡眠的自上而下的控制.
确立了mPFC在启动和调节REM睡眠中的关键作用.
证明了mPFC参与控制REM睡眠特征的阶段性事件.

更多相关视频

Polygraphic Recording Procedure for Measuring Sleep in Mice

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

Quantifying Infra-slow Dynamics of Spectral Power and Heart Rate in Sleeping Mice

Quantifying Infra-slow Dynamics of Spectral Power and Heart Rate in Sleeping Mice

Published on: August 2, 2017

相关概念视频

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...

Sleep-Wake Cycles

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:

Lucid Dreaming

Lucid Dreaming

Lucid dreaming is a unique state of consciousness where an individual realizes they are dreaming while still in the dream. This awareness allows them to manipulate their dream environment consciously. Researchers like Stephen LaBerge have significantly contributed to the understanding of lucid dreams, highlighting that during these dreams, certain areas of the brain, such as the prefrontal cortex, that involve self-awareness and thought evaluation show increased activity.
Studies have shown...

Stages of Sleep

Stages of Sleep

Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...

Functional Brain Systems: Reticular Formation

Functional Brain Systems: Reticular Formation

The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...

Understanding Sleep

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...