一种针对H3K27M的疫苗,用于患有扩散中线质瘤的成年人
Niklas Grassl1,2,3, Isabel Poschke1,4, Katharina Lindner1,4
1DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nature medicine
|September 22, 2023
概括
这项研究表明,H3K27M-vac疫苗是安全的,并且在具有攻击性扩散中线质瘤的患者中引发免疫反应. 一些患者经历了长期缓解,证明了疫苗.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 神经瘤学神经瘤学
背景情况:
- H3K27M突变定义了一个具有攻击性的扩散性质瘤亚型.
- 在临床前模型中,特定于H3K27M的疫苗显示出前景.
- 有H3K27M突变的扩散中线结质瘤的预后不好.
研究的目的:
- 评估H3K27M-vac在成年患者中的安全性和免疫性.
- 评估临床结果,包括无进展和整体存活率.
- 研究H3K27M-vac与抗PD-1疗法结合的潜力.
主要方法:
- 基于同情使用的H3K27M-vac首次在人身上进行临床试验.
- 治疗了8名患有进展性H3K27M+扩散中线质瘤的成年患者.
- 五名患者接受了H3K27M-vac与抗PD-1治疗相结合.
主要成果:
- 在患者中,H3K27M-vac是安全的,耐受性良好.
- 在5/8患者中观察到由CD4+T细胞主导的突变特异性免疫反应.
- 中位数无进展生存时间为6.2个月,中位数整体生存时间为12.8个月.
- 一名患者在表现出强烈的T细胞反应后,在31个多月内实现了完全缓解.
结论:
- 在患有H3K27M+扩散中线质瘤的患者中,H3K27M-vac是安全的和免疫的.
- 疫苗诱导突变特异性的T细胞反应.
- 临床反应,包括持久缓解,表明治疗潜力.
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