饮食饮食模式作为人类肠道微生物群-内分泌素系轴的决定因素
Sophie Castonguay-Paradis1,2,3, Julie Perron1,2, Nicolas Flamand4,5,3
1Centre Nutrition, Santé et Société (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF), Université Laval, Québec, QC, G1V 0A6, Canada.
Scientific reports
|September 22, 2023
概括
饮食模式,而不仅仅是宏观营养素,显著影响肠道微生物群和内分泌素群 (eCBome) 轴. 蔬菜和橄油等特定食物会影响肠道细菌和相关的代谢标志物.
科学领域:
- 人类肠道微生物组研究研究
- 代谢平衡和饮食 代谢平衡和饮食
- 内体大麻素系统 (ECS) 和新陈代谢
背景情况:
- 肠道微生物群和内分泌大麻素体 (eCBome) 对能量平衡至关重要,与饮食有关.
- 了解饮食,肠道微生物和eCBome之间的复杂关系是具有挑战性的,因为它们的复杂性.
研究的目的:
- 研究饮食摄入量与肠道微生物组-eCBome轴之间的相互关系.
- 为了比较整个食物模式与宏观营养素摄入量在这个轴上的影响.
主要方法:
- 招募了195名健康的男女.
- 通过两种方法评估饮食摄入量:全食模式和宏观营养素分析.
- 分析了肠道微生物组合和循环中的N-乙醇胺 (NAE).
主要成果:
- 食物模式,而不是宏观营养素,与肠道微生物群-eCBome轴有显著的关联.
- 特定的食物摄入量 (蔬菜,橄油,精制谷物,肉类) 与NAE水平和肠道微生物家族 (例如Clostridiaceae,Veillonellaceae) 相相关.
- 更高的蔬菜和橄油摄入量与特定的微生物变化和改善的脂质样本 (HDL,LDL) 有关.
结论:
- 在塑造肠道微生物组-eCBome轴上,饮食模式比宏观营养素组成更有影响力.
- 这些发现强调了饮食习惯在通过这个轴调节新陈代谢健康中的重要性.
- 突出了针对微生物组-eCBome轴代谢障碍的个性化饮食干预的潜力.
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