纳米免疫疗法:克服免疫检查点治疗的传递挑战
Seyed Hossein Kiaie1,2, Hossein Salehi-Shadkami3,4, Mohammad Javad Sanaei5
1Department of Formulation Development, ReNAP Therapeutics, Tehran, Iran. hosseinkiaie@gmail.com.
Journal of nanobiotechnology
|September 22, 2023
概括
纳米粒子通过提供免疫检查点抑制剂来增强癌症免疫疗法. 这种方法旨在克服当前治疗方法的局限性,提高疗效和减少不良事件,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 瘤细胞上的免疫检查点 (ICP) 分子抑制抗瘤免疫反应.
- 目前的免疫检查点抑制剂 (ICI) 疗法面临诸如免疫相关不良事件 (irAEs) 和有限的反应率等挑战.
- 优化组合性癌症免疫疗法 (IMT) 策略仍然是一个关键需求.
研究的目的:
- 审查纳米颗粒 (NP) 在增强癌症免疫疗法的作用.
- 探索使用NP来针对性地提供ICI.
- 评估基于NP的药物递送系统 (DDS) 在克服ICP治疗局限性的潜力.
主要方法:
- 审查当前的临床和临床前试验数据.
- 对提供ICI (抗体,RNA,小分子) 的基于NP的策略的分析.
- 在单一和组合IMT中使用NP的受控DDS的检查.
主要成果:
- 国家产品提供了一个可行的和有效的平台,以提供有针对性的ICI.
- NP-药物合物和封装物提高治疗疗效.
- 将DDS与ICP治疗结合起来,对癌症治疗有很大的前景.
结论:
- 纳米粒子介导的药物递送是克服免疫检查点阻塞疗法的局限性的有希望的策略.
- 使用NP进行针对性的ICI治疗可以增强抗瘤免疫反应.
- 对基于NP的结合性癌症免疫疗法的进一步临床研究是有必要的.
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