与海鲜相关的ctx-Negative Vibrio mimicus爆发,导致类似霍乱的疾病,佛罗里达州,美国
Emerging infectious diseases
|September 22, 2023
概括
活模仿菌在佛罗里达州引起了严重的海鲜疫情. 即使没有霍乱毒素基因,这些细菌也可能导致严重的,类似霍乱的疾病,需要住院治疗.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 食品安全 食品安全
背景情况:
- 仿真菌是已知导致海鲜相关的胃肠炎的原因.
- 疫情突出了鉴定和表征细菌病原体对公共卫生的重要性.
- 了解毒性因素对于预测疾病严重程度至关重要.
研究的目的:
- 在佛罗里达州海鲜相关的疫情中涉及的Vibrio mimicus菌株的特征.
- 为了确定这些菌株中的毒性决定因素.
- 评估Ctx阴性菌株引起的霍乱类疾病的可能性.
主要方法:
- 从临床和食品样本中分离和识别细菌.
- 分子分析检测毒性基因,包括霍乱毒素 (ctx) 基因.
- 对病例患者的临床数据审查.
主要成果:
- 在佛罗里达州,Vibrio mimicus被确定为与海鲜相关的疫情的致病原体.
- 所有研究的菌株对霍乱毒素 (ctx) 基因呈阴性.
- 菌株拥有编码其他毒性因子的基因,如血解素,蛋白酶和各种分泌系统 (I-IV和VI类型).
- 6名病例患者中有4人需要住院治疗,其中1人因严重腹需要重症监护.
结论:
- 仿真菌病毒可以引起严重的胃肠道疾病和类似霍乱的疾病,即使没有霍乱毒素.
- 除了霍乱毒素之外的病毒性因素有助于Vibrio mimicus的致病性.
- 这强调了需要进行警的监测,并迅速临床识别来自海鲜的Vibrio感染.
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