相关实验视频
Updated: Jul 16, 2025

08:50
Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
7.0K
癌症免疫治疗中的非编码RNA:预测生物标志物和点
Murad Alahdal1,2, Eyad Elkord3,4
1Johns Hopkins All Children's Hospital, St, Petersburg, Florida, USA.
Clinical and translational medicine
|September 22, 2023
概括
识别非编码RNA (ncRNA) 生物标志物对于预测癌症免疫治疗反应至关重要. 本综述强调了可以预测治疗疗效和改善患者治疗结果的关键ncRNA生物标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫治疗是一种免疫疗法.
背景情况:
- 标准化免疫疗法反应的预测生物标记因遗传,瘤微环境和表观遗传变异而具有挑战性.
- 非编码RNAs (ncRNAs) 正在成为监测免疫治疗疗效的有希望的生物标志物.
研究的目的:
- 审查用于预测癌症免疫治疗反应的关键非编码RNA (ncRNA) 生物标志物.
- 讨论ncRNAs作为免疫治疗中的预测工具和治疗点的潜力.
主要方法:
- 在接受各种免疫疗法治疗的癌症患者中报告ncRNA生物标志物的研究文献综述.
- 分析特定的ncRNAs (例如,miR-125b-5p,miR-153,miR-148a-3p,miR-375) 和它们的预测值.
主要成果:
- 特定的ncRNA显示出对抗PD-1,CAR-T细胞疗法和癌症疫苗的预测反应的潜力.
- 降低的miR-125b-5p预测了用抗PD-1治疗的非小细胞肺癌的积极结果.
- 在各种癌症中,ncRNA水平与T细胞活性和治疗疗效相关.
结论:
- ncRNAs代表了癌症免疫治疗的有价值的预测生物标志物.
- 需要进一步的研究来建立标准化的ncRNA生物标志物,以便早期预测临床反应.
- 在免疫治疗中,ncRNA具有作为预测工具和治疗点的潜力.
相关概念视频
lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Tumor Immunotherapy
551
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
551
Cancer Vaccines
396
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
396
MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
Adaptive Mechanisms in Cancer Cells
5.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K

