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在患有双相情感障碍和重度抑郁症的患者中使用代谢组分析搜索血清生物标志物

Xiao-Li Sun^1,2, Li-Na Ma^1,2, Zhen-Zhu Chen^1,2

¹Department of Psychiatry, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China.

Frontiers in psychiatry

|September 22, 2023

概括

双极性障碍 (BD) 和主要抑郁障碍 (MDD) 的血清代谢概况与健康对照显著不同. 特定的代谢物,如酸和泛酸,可能有助于区分这些疾病,改善情绪障碍的诊断和治疗.

科学领域:

精神病学是一个精神病学.
代谢学代谢学代谢学
生物标志物发现发现

背景情况:

双极性障碍 (BD) 和严重抑郁障碍 (MDD) 是常见的精神疾病,症状重叠.
将BD误诊为MDD可能会对治疗和患者的结果产生负面影响.
需要客观的诊断生物标志物来区分BD和MDD.

研究的目的:

确定血清代谢生物标志物,以区分双相情感障碍 (BD) 和主要抑郁障碍 (MDD).
为了研究BD,MDD和健康对照之间的代谢特征差异.

主要方法:

来自BD (n=59),MDD (n=14) 和健康对照组 (n=10) 的患者的血清样本使用核磁共振 (NMR) 光谱分析.
部分最小平方差分分析 (PLS-DA) 和直角 PLS-DA (OPLS-DA) 用于数据分析.
鉴定了代谢物差异 (VIP> 1和p < 0.05),并使用MetaboAnalyst 5.0.0分析了这些途径.

主要成果:

在BD和健康对照组之间,以及在MDD和健康对照组之间观察到显著的代谢表型差异.
与对照组相比,BD组显示3-基黄油酸,n-乙糖蛋白,泛多酸,甘油和脂质水平升高,乳酸和酸含量较低.
与对照组相比,MDD组表现出高水平的3-基黄油酸,n-乙糖蛋白,酸盐,胆和脂质,与较低的酸和甘油相比,MDD组表现出高水平的3-基黄油酸,n-乙糖蛋白,酸盐,胆和脂质.

结论:

糖脂代谢与BD和MDD有关.
酸盐代谢在MDD中起着重要作用.
酸盐,胆和酸盐可以作为MDD的生物标志物,将其与BD区分开来,而泛酸可能是BD的生物标志物,将其与MDD区分开来.

关键词:

生物标志物生物标志物双相情感障碍是双相情感障碍的一种疾病.大型抑郁症主要是抑郁症.代谢学代谢学核磁共振是一种核磁共振.

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