手术作为突发静脉血栓栓塞的触发因素:基于人口的病例交叉研究的结果
Dana Meknas1,2, Sigrid K Brækkan1,3, John-Bjarne Hansen1,3
1Department of Clinical Medicine, Thrombosis Research Group, UiT-The Arctic University of Norway, Tromsø, Norway.
TH open : companion journal to thrombosis and haemostasis
|September 22, 2023
概括
大型手术显著增加了静脉血栓栓塞 (VTE) 的风险. 然而,这种风险的部分原因是其他因素,如常常伴随手术的固定和感染.
科学领域:
- 医学研究 医学研究
- 流行病学 流行病学
- 临床研究 临床研究
背景情况:
- 手术是已知的静脉血栓塞栓症 (VTE) 的过渡性危险因素.
- 大型手术作为VTE触发器的特定影响需要使用强大的研究设计进行进一步的研究.
研究的目的:
- 检查大手术作为引发事件VTE的作用.
- 在基于人群的案例交叉研究中调整其他同时出现的VTE触发因素.
主要方法:
- 一项涉及特罗姆索研究队列中的531例无癌症静脉瘤病例的病例交叉研究.
- 使用条件后勤回归来估计与大手术相关的VTE的几率比率 (ORs).
- 在VTE前90天和前四个90天的控制期评估了触发因素.
主要成果:
- 手术被确定为16.0%的危险时期的触发因素,而对照期为1.8% (OR=11.40).
- 与手术相关的VTE的OR在调整为固定,感染,创伤,输血和中央静脉导管后降至3.31.
- 调解分析表明,固定和感染解释了51.4%的手术-VTE关联.
结论:
- 大型手术是VTE的重要触发因素.
- 手术与静脉瘤风险之间的关联部分由其他因素介导,特别是固定和感染.
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