负担得起的癌症免疫治疗的未来
Niels Schaft1,2,3,4, Jan Dörrie1,2,3,4, Gerold Schuler1,2,3
1Department of Dermatology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.
Frontiers in immunology
|September 22, 2023
概括
癌症免疫疗法已经取得了重大进展,但仍然昂贵. 本综述探讨了使这些挽救生命的治疗方法更实惠和更容易获得的策略,改善了它们的成本效益比率,以实现更广泛的患者获取.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 卫生经济学 卫生经济学
背景情况:
- 癌症免疫疗法在过去二十年里彻底改变了治疗方法.
- 关键的进展包括检查点抑制剂和仿真抗原受体 (CAR) -T细胞,在不同类型的癌症中具有不同的疗效.
- 新兴的积极免疫策略和高治疗成本带来了可访问性挑战.
研究的目的:
- 审查使癌症免疫疗法更负担得起的策略.
- 提高现有和新兴癌症治疗的成本效益比.
- 确定改善新型癌症疗法可获得性的方法.
主要方法:
- 讨论利用具有成本效益的试剂来利用"感冒瘤"抗原性.
- 探索基于微生物组的产品用于癌症治疗和诊断.
- 对采用细胞疗法 (ACT) 的成本降低措施的分析,包括"现成"产品.
- 评估更便宜的免疫疗法平台,如RNA或基疫苗和共享抗原疫苗.
- 预测生物标志物和负担得起的免疫组织化学标志物的评估,以指导治疗.
主要成果:
- 该审查确定了减少免疫疗法成本的多种途径.
- 战略侧重于更有效地利用现有平台,并开发新的,具有成本效益的方法.
- 通过有针对性的生物标志物选择和负担得起的试剂使用,预计会改善成本效益比率.
结论:
- 让癌症免疫疗法负担得起,对于公平的患者获取至关重要.
- 需要采用多方面的方法,包括降低试剂成本,创新平台和优化诊断.
- 未来的研究应该专注于验证具有成本效益的策略,以扩大癌症免疫治疗的影响.
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